Aurora police said Saturday that the men who died and the officer were shot Friday night near the University of Colorado Anschutz Medical Campus.
Police said officers were investigating a reported fight when they heard gunshots. They found several people, including a juvenile, had been hurt.
The department said another person then fired at police.
The wounded officer has been released from the hospital.
The suspect and a juvenile who were injured remained at hospitals. No information has been released about their conditions or the identities of those involved, including the officer.